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    货号
    种属
    载体
    描述
    价格
    周期
    PR10377
    Mouse
    pDRIVE5-SEAP
    3500
    3-4 周

    产品参数

    Gene Promoter: Tyr : Tyrosinase
    Specificity: Melanocytes & melanoma
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-Tyr / Tyr(mouse) Map 产品说明书(点击下载)

    pDRIVE-Tyr / Tyr(mouse) Sequence 产品说明书(点击下载)

    产品说明

    Description:
    Tyrosinase, the rate-limiting enzyme in melanin synthesis, is expressed specifically in pigment-producing cells. Expression of tyrosinase is regulated by cyclic AMP (cAMP). The M-box 70-bp upstream from the TATA-box and the E-box located downstream the TATA-box, near the initiator site, are involved in the regulation of the tyrosinase promoter activity by cAMP [1]. Melanoma-specific expression of a transgene can be achieved by using the tyrosinase promoter [2], this targeted expression being further amplified by addition of the melanocyte-specific enhancer.


    1. Bertolotto C. et al. 1996. Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. J Cell Biol. 134(3):747-55.
    2. Vile R. et al. 1994. Acomparison of the properties of different retroviral vectors containing the murine tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes. Gene Ther. 1(5):307-16.

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