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    货号
    种属
    载体
    描述
    价格
    周期
    PR10364
    Mouse
    pcDNA3.1-EGFP
    5000
    3-4 周

    产品参数

    Gene Promoter: Tyrosinase Related Protein
    Specificity: Melanocytes & melanoma
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-TRP1(mouse) Map 产品说明书(点击下载)

    产品说明

    Description:
    The TRP1 gene encodes the tyrosinase-related protein 1, an enzyme involved in the process that converts tyrosinase to melanin pigments. Expression of TRP1 is restricted to melanocytes and melanoma cells partly as a consequence of transcriptional regulation of its mRNA. The TRP1 promoter shares with the tyrosinase promoter an 11-bp motif termed the M box located upstream of the TATA box. This M box plays a key role in the regulation of the TRP1 expression by cyclic AMP (cAMP) [1]. Tissue-specific expression of transgenes, such as the IL-2 and HSV1-tk genes, driven by the TRP1 promoter has been demonstrated in murine model systems, achieving marked antitumor effects [2].


    1. Bertolotto C. et al. 1996. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia Mol Cell Biol. 18(2):694-702.
    2. Hart IR. 1996. Tissue specific promoters in targeting systemically delivered gene therapy. Semin Oncol. 23(1):154-8.

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