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    货号
    种属
    载体
    描述
    价格
    周期
    PR10324
    Human
    pDrive
    3500
    3-4 周

    产品参数

    Gene Promoter: E2F1 Transcription factor 1
    Specificity: Tumor
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-E2F-1(human) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-E2F-1(human) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-E2F-1(human) Sequence 产品说明书(点击下载)

    产品说明

    Description:
    E2F transcription factors are critical regulators of cell growth and are often overexpressed in cancer cells because of the frequent aberrations in the pRb/E2F/p16(INK4a) pathway. E2F-1 is a transcription factor that activates its own transcription and that of other genes involved in the G(1) to S transition phase of the cell cycle. The E2F-1 promoter was used in an adenovirus to drive the expression of the E1A adenoviral gene and induced selective killing in a variety of tumor cell lines [1].


    1. Tsukuda K. et al. 2002. An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell. Cancer Res 62(12):3438-47.

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