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    启动子产品信息

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    货号
    种属
    载体
    描述
    价格
    周期
    PR10319
    Human
    pDrive
    3500
    3-4 周

    产品参数

    Gene Promoter: CXC-Chemokine receptor 4
    Specificity: Tumor
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-CXCR4(human) Map 产品说明书(点击下载)

    产品说明

    Description:
    CXCR4 is the receptor for the chemokine SDF1 and a coreceptor for HIV-1 entry. The expression of CXCR4 is upregulated in many types of cancers but low in the liver and other major organs. The CXCR4 promoter contains a TATAbox, a nuclear respiratory factor-1 (NRF-1) site, and for GC boxes [1].
    A 279 bp fragment of the CXCR4 promoter was shown to have a “tumor-on” status in vitro and in vivo particularly in melanoma and breast cancers [2].


    1. Moriuchi M. et al., 1997. Cloning and analysis of the promoter region of CXCR4, a coreceptor for HIV-1 entry. J Immunol. 159(9):4322-9.
    2. Zhu ZB. et al., 2004. Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter. Gene Ther. 11(7):645-8.

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