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    启动子产品信息

    订购信息

    货号
    种属
    载体
    描述
    价格
    周期
    PR10318
    Mouse
    pGL3-basic
    5000
    3-4 周

    产品参数

    Gene Promoter: Cyclo-oxygenase 2 isoform
    Specificity: Tumor
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-COX-2(human) Map 产品说明书(点击下载)

    pDRIVE-COX-2(mouse) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-COX-2(human) Map 产品说明书(点击下载)

    产品说明

    Description:
    COX-2 is an inducible isoform of cyclooxygenase. Expression of COX-2 is undetectable under physiological conditions but up-regulated in many malignant tumors. COX-2, which is a PKC-dependent gene, is important for the genesis of cancer. COX-2 promoter contains a cAMP response element and sites for AP-2 and NF-κB that are both PKC-responsive cis-elements. COX-2 promoter has been used to target gene expression in pancreatic [1], gastrointestinal [2] and ovarian cancers. Similar levels of expression of luciferase and HSVtk genes were obtained with COX-2 and CMV promoters.


    1. Wesseling JG et al. 2001. Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma. Cancer Gene Ther 8(12):990-6.
    2. Yamamoto M et al. 2001. Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy ofgastrointestinal cancers. Mol Ther. 3(3):385-94.

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