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    货号
    种属
    载体
    描述
    价格
    周期
    PR10297
    Human
    pGL3-basic
    4000
    3-4 周

    产品参数

    Gene Promoter: Cholecystokinin-A receptor
    Specificity: Pancreatic cancer
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-CCKAR(human) Map 产品说明书(点击下载)

    产品说明

    Description:
    Cholecystokinin (CCK) is a gut peptide hormone known to stimulate postprandial gallbladder contraction and pancreatic enzyme secretion. CCK plays also an important role in pancreatic carcinogenesis. The CCK-A receptor (CCKAR) is predominantly expressed in human pancreatic cancer [1]. A 0.7 kb fragment of the CCKAR promoter was reported to drive the expression of the luciferase gene selectively in pancreatic cancer cells and in not normal cells [2]. This fragment lacks a typical TATA box but contains two GC-box motifs [3].


    1. Moonka R. et al., 1999. Cholecystokinin-A receptor messenger RNA expression in human pancreatic cancer. J Gastrointest Surg. 3(2):134-40.
    2. Li Z. et al., 2005. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 236(1):58-63.
    3. Takata Y,. et al., 2002. Promoter analysis of human cholecystokinin type-A receptor gene. J Gastroenterol. 37(10):815-20.

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