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    货号
    种属
    载体
    描述
    价格
    周期
    PR10276
    Human
    pDrive
    3500
    3-4 周

    产品参数

    Gene Promoter: Wiskott-Aldrich Syndrom Protein
    Specificity: Hematopoietic cells
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

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    产品说明

    Description:
    Wiskott-Aldrich syndrome protein (WASP) is a major cytoskeletal regulator expressed in hematopoietic cells. Mutations in the WASP gene result in an immune deficiency with thrombocytopenia. A 500 bp fragment from the proximal WASP gene promoter (extending from bases -1 to -499 from the transcriptional start site) was shown to direct hematopoietic-specific expression of a transgene [1]. This fragment contains four potential binding sites for hematopoietic transcription factors (two for ets-1, one for c-Rel, and one for PU.1). Transduction of WASP-deficient cells with a lentiviral expressing the WASP gene under the control of the proximal WASP gene promoter resulted in physiological levels of WASP expression [2]. The WASP expression levels were 135-350 times lower in non-hematopoietic cells.


    1. Petrella A. et al., 1998. A 5' regulatory sequence containing two Ets motifs controls the expression of the Wiskott-Aldrich syndrome protein (WASP) gene in human hematopoietic cells. Blood. 91(12):4554-60.
    2. Martin F. et al., 2005. Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences. Gene Ther. 12(8):715-23.

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