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    货号
    种属
    载体
    描述
    价格
    周期
    PR10256
    Human
    pDrive
    3500
    3-4 周

    产品参数

    Gene Promoter: Nephrin
    Specificity: Podocytes
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, ect.

    产品说明书

    pDRIVE-NphsI(human) Map 产品说明书(点击下载)

    pDRIVE-NphsI(human) Sequence 产品说明书(点击下载)

    产品说明

    Description:
    Nephrin is a transmembrane protein that belongs to the immunoglobulin superfamily and is localized to the slit diaphragms that are a critical component of the glomerular filtration barrier in the kidney. A 1.25 kb fragment of the nephrin gene promoter, which includes the initiation codon and immediate 5’-flanking region, is capable of directing podocyte-specific expression of a β-galactosidase transgene in vivo [1,2]. This promoter lacks a TATA box but contains GATA binding sites and E-box consensus sequences. An enhancer was identified within the proximal promoter which is activated by the Wilms tumor suppressor protein (WT1) in vitro [3].


    1. Wong MA. et al., 2000. Identification and characterization of a glomerular-specific promoter from the human nephrin gene. Am J Physiol Renal Physiol. 279(6):F1027-32.
    2. Moeller MJ. et al., 2002. Two gene fragments that direct podocyte-specific expression in transgenic mice. J Am Soc Nephrol. 13(6):1561-7.
    3. Guo G. et al., 2004. WT1 activates a glomerular-specific enhancer identified from the human nephrin gene. J Am Soc Nephrol. 15(11):2851-6.

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