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    货号
    种属
    载体
    描述
    价格
    周期
    PR10243
    Mouse
    pUC57
    1000
    2-3 周

    产品参数

    Gene Promoter: Interferon Beta
    Specificity: Hematopoietic cells
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-INF-β(mouse) Map 产品说明书(点击下载)

    产品说明

    Description:
    Expression of the interferon-beta (IFN-β) gene is induced by a variety of agents, including viruses and double-stranded RNA (dsRNA), and is also strongly repressed in uninduced cells, a requirement imposed by the cytotoxic properties of IFN-β. The functional IFN-β promoter resides within a 170 bp fragment located 5’ of the coding sequence [1]. This region contains four binding sites for transcription factors such as NF-κB and IRF-1 that act as activators, as well as putative negative regulatory domains. Fusion of the IFN-β promoter region to the luciferase gene was shown to render the expression of the reporter gene inducible by dsRNA [2].


    1. Dirks W. et al., 1989. Isolation and functional characterization of the murine interferon-beta 1 promoter. J Interferon Res. 9(1):125-33.
    2. King P& Goodbourn S. 1994. The betainterferon promoter responds to priming through multiple independent regulatory elements. J Biol Chem. 269(48):30609-15.

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