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    货号
    种属
    载体
    描述
    价格
    周期
    PR10206
    Rattus
    pDRIVE5-SEAP
    3500
    3-4 周

    产品参数

    Gene Promoter: Elastase-1
    Specificity: Pancreatic acinar cells
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-Elastase-1(rat) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-Elastase-1(rat) Map 产品说明书(点击下载)

    产品说明

    Description:
    The elastase gene is one of the pancreatic digestive enzyme genes which is activated in a stage- and site- specific manner during development of the mammalian gut. The rat elastase 1 promoter is a 213 bp fragment comprised of the core promoter (-72 to +8) and the enhancer (-205 to -73). The elastase 1 promoter was shown to direct the expression of a human growth hormone transgene in pancreatic acinar cells, stomach, duodenum, and colon. This pattern of selective expression limited to the gastroenteropancreatic organ system is specified by the A element, one of three functional elements in the elastase 1 enhancer.


    1. Ornitz DM. et al. 1985. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 313(6003):600-2.
    2. Rose SD. et al. 1994. A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut. Mol Cell Biol 14(3):2048-57.

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