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    货号
    种属
    载体
    描述
    价格
    周期
    PR10195
    Human
    pGL3-basic
    4000
    3-4 周

    产品参数

    Gene Promoter: Homolog of Macrosialin
    Specificity: Macrophages
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-CD68(human&mouse) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-CD68(mouse) Map 产品说明书(点击下载)

    pDRIVE5-SEAP-CD68(mouse) Sequence 产品说明书(点击下载)

    产品说明

    Description:
    Murine macrosialin and its human homolog CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells. The CD68 gene promoter directs macrophage-specific expression. Although the promoter lacks a classical TATA box, it contains other protein binding sites consistent with preferential monocyte/macrophage gene expression1. CD68 promoter has been used to achieve constitutive expression of IL-10 specifically in macrophages [2].


    1. Jiang Z. et al. 1998. Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein. Genomics 50(2):199-205.
    2. Lang R.et al. 2002. Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter. J Immunol. 168(7):3402-11.

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