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    货号
    种属
    载体
    描述
    价格
    周期
    PR10162
    pDRIVE5-SEAP
    3500
    3-4 周

    产品参数

    Gene Promoter: Alb: Albumin
    Specificity: Liver
    Backbone: pDRIVE, pDRIVE5-SEAP, pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

    产品说明书

    pDRIVE-SV40/bAlb(bovine) Map 产品说明书(点击下载)

    产品说明

    Description:
    The albumin gene is transcribed at very high levels in fetal liver and, unlike the adjacent AFP gene, remains active after birth. A small segment of the bovine albumin 5’flanking region, from -170 to +20, is sufficient for promoter activity and specificity [1]. This segment contains the CCAAT box, TATA box and the binding site of HNF1, a liver specific transcription factor. The albumin promoter is a liver-specific promoter. It can drive the expression of a transgene, such as HSV-tk, specifically in hepatocellular carcinoma cells eliminating the risk of systemic toxicity of GCV [2].


    1. Power SC. et al. 1994. Isolation and functional analysis of the promoter of the bovine serum albumin gene. Biochem Biophys Res Com 203(3):1447-1456.
    2. Kuriyama S. et al. 1997. Tissue-specific expression of HSV-tk gene can induce efficient antitumor effect and protective immunity to wild-type hepatocellular carcinoma. Int J Cancer. 71(3):470-5.

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