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    启动子产品信息

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    货号
    种属
    载体
    描述
    价格
    周期
    PR10052
    Human
    pUC57
    4000
    2-3 周

    产品参数

    Gene Promoter: Endothelin-1
    Specificity: Ubiquitous
    Backbone: pGL3-basic, pUC57, pcDNA3.1-EGFP, ect.

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    产品说明

    Description:
    Endothelin-1 (ET-1) is a peptide synthesized by endothelial cells both in culture and in vivo. ET-1 induces contraction of smooth muscle cells and stimulates growth in a variety of mesenchymal cell types. We cloned and sequenced the human ET-1gene. The objective of the work reported here was to determine which cis-acting sequence in the ET-1 promoter region are important for transcription of the gene. Using delection mutants of the ET-1 promoter, promoter reconatitution experiments, and enhanser trap experments, we have identified a 119-base pair sequence containing two regions necessary for ET-1 promoter function. This sequence allows expression of a heterologous promoter in endothelial cells.

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